In a laboratory in Bonn, a blood cell belonging to an 80-year-old person turned 20.
The researchers, led by Oliver Brüstle of the University of Bonn, took blood-cell precursors from an elderly donor and reprogrammed them into neural stem cells. They then measured the cells with epigenetic clocks — chemical fingerprints on DNA that researchers use to estimate molecular age — and found the clocks had run backward more than 60 years. The 80-year-old cells registered as younger than 20. The whole reset took 50 days. The work was published in the journal Aging Cell and confirmed, for the record, that the German government has not yet been asked for it.
It has been asked by everyone else.
“The reprogramming was complete and measurable,” Brüstle has said of the result, in the cautious manner of men who know the internet. He also noted, in the same interview, that his laboratory is in Bonn, that the funding is public, and that there is no company. This last sentence has been the least popular part of the paper.
Nine hours after the study was published, a Delaware startup called Re:You circulated an updated pitch deck to investors. Its founder, Trey Holloway, whose previous companies include a subscription dog-food brand and a failed attempt to license his own face, has since taken meetings in Palo Alto.
“The epigenetic reset is, at bottom, a supply-chain problem,” Holloway told this newspaper, in a voice trained by conference stages. “Germany solved the science. We solve distribution. Youth, delivered.” He would not confirm whether Re:You has licensed the German method. The German method has not been licensed to anyone, by anyone, in any country.
Back in Bonn, the team’s senior postdoctoral researcher, who asked to be identified only as the person who actually ran the assays, was offered a position by “a top-five American lab” the day the paper went live. He declined. His reason, conveyed with visible fatigue, was that his laboratory has a group Christmas party in December and “they have never once made me feel like a subscription.”
The scientific caution, which Americans have historically treated as an intro track, deserves repeating: the study reversed the molecular clock of cells in a dish, not of a person. Nobody in Bonn has a young 80-year-old. What they have is evidence that age, at the level of chemistry, is not a one-way street, which is either a modest finding or the end of everything, depending on whether you are a cell biologist or a Delaware LLC.
Asked what he thought of the American reaction, Brüstle answered as his country does.
“The cells are young,” he said. “The scientist who made them young is 58. I am aware this is the only part of the study the Americans have been unable to purchase.”
The reset took 60 years off, in 50 days. American companies have requested it in 30.